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KMID : 0613820140240010020
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Journal of Life Science
2014 Volume.24 No. 1 p.20 ~ p.25
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Curcumin Induces Recovery from Indomethacin-Induced Gastric Mucosal Lesions in Rats
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Kim Jeong-Hwan
Kim Byung-Woo
Kwon Hyun-Ju
Kim Yeon-Hee
Nam Soo-Wan
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Abstract
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In the present study, the curative effect of curcumin on indomethacin-induced gastric mucosal lesions in rats was investigated. Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID), with serious side effects, including erosion, ulcerative lesions, and petechial bleeding in the mucosa of the stomach. Gastric mucosal lesions were caused by oral administration of 25 mg/kg of indomethacin. Various doses (10, 50, and 100 mg/kg) of curcumin were treated for 3 days by oral gavage. Indomethacin clearly increased the gastric ulcer area in the stomach, and curcumin significantly decreased the gastric ulcer area in a dose-dependent manner. Curcumin also markedly inhibited lipid peroxidation in the gastric mucosa and activated radical scavenging enzymes, such as superoxide dismutase (SOD), catalase, and glutathione peroxidase, in a dose-dependent manner. These results suggest that curcumin can induce recovery from indomethacin-induced gastric mucosal lesions through inhibition of lipid peroxidation and activation of radical scavenging enzymes, such as SOD, catalase, and glutathione peroxidase. Curcumin appears to be a powerful free radical quencher, and it may offer an attractive strategy for healing gastric mucosal lesions in humans.
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KEYWORD
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Curcumin, gastric mucosal lesions, lipid peroxidation, oral gavage, radical scavenging enzymes
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